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International Journal of Medicine Sciences

Vol. 6, Issue 1, Part A (2024)

Comparative study of beta-blockers versus calcium channel blockers in reducing stroke risk among hypertensive patients with atrial fibrillation

Author(s):

Kamal Rija Mohammed Al isawi and Hazim Ismael Ghazzay

Abstract:

Background: Hypertension is a major risk factor for stroke, especially with patients with atrial fibrillation (AF). Beta-blockers and calcium channel blockers are two general classes of antihypertensive drugs whose comparative efficacy in lowering stroke risk and other cardiovascular outcomes is still not well elucidated.
Objective: For the purpose of determining differences between beta-blockers and CCBs in regard to stroke risk, blood pressure control, and the prevention of AF reoccurrence in hypertensive AF patients.
Methodology: This was a retrospective cohort study and included 400 hypertensive AF patients attending Fallujah and Ramadi Teaching Hospitals from February to September 2024. A total of 400 patients was recruited, 200 in each group, that s of beta-blockers and CCBs. The effects of stroke incidence, blood pressure control rate, AF, recurrence, and mortality were evaluated by Cox proportional risk model and Kaplan-Meier curve survival.
Results: Beta-blockers are associated with a trend of lowering the total stroke rate; 4% of patients in the beta-blocker group and 9% of patients in the CCBs group experienced a total stroke (p = 0.01), and the ischemic stroke rate; 3% of patients taking beta-blockers and 7% of patients taking CCBs endured an Ischemic stroke (p = 0.01). They also offered more antihypertensive management and less reoccurring AF (7% vs. 13%, n = 0.04). Newcomers cardiovascular mortality trends are, albeit not statistically significant, favorable to beta-blockers.
Conclusion: Compared with CCBs, beta-blockers are more effective for the reduction of stroke risk and prevention of AF reccurrence in hypertensive AF patients. More studies are required by authors for knowing how they affect mortality. Beta-receptor blockers should be prescribed to patients with the enhanced risk of ischemic stroke.
 

Pages: 25-34  |  189 Views  54 Downloads


International Journal of Medicine Sciences
How to cite this article:
Kamal Rija Mohammed Al isawi and Hazim Ismael Ghazzay. Comparative study of beta-blockers versus calcium channel blockers in reducing stroke risk among hypertensive patients with atrial fibrillation. Int. J. Med. Sci. 2024;6(1):25-34. DOI: 10.33545/26648881.2024.v6.i1a.47