Reza Samie, Sara Masihi, Behdad Amirgholami and Hamid Galehdari
Introduction: Recurrent pregnancy loss is characterized by having 3 or more miscarriages. After two or three miscarriages, a thorough physical examination and testing are recommended. In a small number of couples who have repeated miscarriages, one partner has chromosomal abnormalities. We assessed the prevalence of these abnormalities in couples referred to our perinatal clinics at Imam Hospital in Ahvaz.
Material and Method: This study was done on 320 couples who visited the perinatal clinic at Ahvaz's Imam Khomeini Hospital in a 2-year period, from 2021/03 to 2023/03 and had multiple abortions (more than three). The patients were initially evaluated, and a complete medical history was recorded. In order to assessment anatomical abnormalities vaginal sonography was used, along with antiphospholipid antibody syndrome testing and sperm analysis also was done. If the outcomes were not positive, in 142 cases both the husband and wife underwent karyotyping using the G- banding or CGH Array method, and the data were input into the software for Statistical analysis.
Result: 142 couples (284 people) were evaluated in this survey, 5 people with chromosomal abnormalities were detected (3.52% of couples) (1.76%people), 2.11% of females (3 females) in the ages ranged 18 to 45(mean 30.6), and 1.4% of men (2 men) in the range of 21 to 53 (mean: 35.3).
Conclusion: The prevalence of chromosomal abnormalities was 3.52%, which of course is where we didn’t have abnormal initial findings. It seems performing chromosomal analysis in couples suffering repeated miscarriages should be in secondary priority, and first, the analysis in terms of anatomical and hormonal problems and immunological factors should be done.
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