Vol. 3, Issue 1, Part A (2021)

Background: Serial arterial blood gases analysis in children with respiratory distress under mechanical ventilation is the major tool for management and treatment of these patients, which requires experienced personnel to properly arterial sampling. In pediatrics because of arterial puncture may cause complications, it is difficult to evaluate arterial blood gases repeatedly. This study was aimed to determine the validity of pvo2 and pvco2 in measuring of desired FiO2 and desired tidal volume on children under mechanical ventilation admitted to picu. Materials and Methods: In this cross-sectional study, 50 patients who were admitted to the picu of Tabriz Children's Center with respiratory distress and underwent mechanical ventilation were included in the study. Arterial blood samples were taken to determine pao2 and paco2 and venous blood samples were taken simultaneously to determine pvo2 and pvco2. Pao2 and paco2 obtained from arterial blood were considered as the gold standard for measuring desired tidal volume and FiO2. All samples were assessed by a blood gas analyzer. The desired tidal volume and the desired FiO2 values were calculated using the formula. Results: The results showed that the use of desired FiO2 by venous sampling instead of arterial sampling and use of desired tidal volume by venous sampling instead of arterial sampling have a sensitivity of 91.54% and specificity of 68.67% and a sensitivity of 90.12% and specificity of 63.89%, respectively. Conclusion: According to the results in this study, concluded that the use of pvo2 and pvco2 in calculating desired FiO2 and desired tidal volume have acceptable validity.