Neurofibromatosis also as Von Recklinghausen was able an association between the cutaneous and tumor lesions. This disorder is divided into neurofibromatosis type 1, neurofibromatosis type 2 and schwannomatosis. Neurofibromatosis type I, in which the nerve tissue grows tumors that may be benign and may cause serious damage by compressing nerves and other tissues. More than half of the people affected by neurofibromatosis have a family history of it with some type of genetic mutation. This paper presents a case of Von Recklinghausen with clinical signs especially in eye. Some treatments for the patient’s quality of life are discussed.